Notice of Intent to Publish a Funding Opportunity Announcement for HEAL Initiative: NIH-DOD-VA Pain Management Collaboratory � Pragmatic and/or Implementation Science Demonstration Projects ((UG3/UH3) Clinical Trial Required)

The National Center for Complementary and Integrative Health (NCCIH) intends to publish a Notice of Funding Opportunity (NOFO) to solicit UG3/UH3 phased cooperative agreement research applications to conduct efficient, large-scale pragmatic clinical trials and/or implementation science demonstration projects within the infrastructure of the NIH-DOD-VA Pain Management Collaboratory (PMC) on nonopioid approaches to the management of pain and other comorbid conditions, including complementary and integrative approaches used alone and in combination with standard care (e.g., mindfulness meditation combined with standard pharmaceutical treatment), and improving prevention and treatment for opioid misuse and addiction in U.S. Veterans, military personnel, and their families. Supporting the trials, the PMC has established a coordinating center that provides national leadership and technical expertise for all aspects of health care system (HCS)-focused research including assistance to UG3/UH3 grant recipients.This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects.The NOFO is expected to be published in Fall 2024 with an expected application due date in November 2024.This NOFO will utilize the UG3/UH3 activity code. Details of the planned NOFO are provided below.